Selected publications
  • Mingyi Zhang, Cuncun Qiao, Guodong Luan*, Quan Luo*, Xuefeng Lu, 2020, Systematic Identification of Target Genes for Cellular Morphology Engineering in Synechococcus elongatus PCC7942, Frontiers in Microbiology, 11:1608.
  • Yue Qiao, Weihua Wang*, Xuefeng Lu*, 2020, Engineering cyanobacteria as cell factories for direct trehalose production from CO2, Metabolic Engineering, 62:161-171.
  • Yue Qiao, Weihua Wang*, Xuefeng Lu*, 2020, High Light Induced Alka(e)ne Biodegradation for Lipid and Redox Homeostasis in Cyanobacteria, Frontiers in Microbiology, 11:1659.
  • Ângela Brito, Jorge Vieira, Cristina P. Vieira, Tao Zhu, Pedro Leão, Vitor Ramos, Xuefeng Lu, Vitor Vasconcelos, Muriel GUGGER, Paula Tamagnini*, 2020, Comparative genomics discloses the uniqueness and the biosynthetic potential of the marine cyanobacterium Hyella patelloides, Frontiers in Microbiology, 11:1527.
  • Viktoria Reimann, Marcus Ziemann, Hui Li, Tao Zhu, Juliane Behler, Xuefeng Lu , Wolfgang R Hess*, 2020, Specificities and functional coordination between the two Cas6 maturation endonucleases in Anabaena sp. PCC 7120 assign orphan CRISPR arrays to three groups, RNA Biology, doi: 10.1080/15476286.2020.1774197.
  • Min Wang, Guo dong Luan*, XuefengLu*, 2020, Engineering ethanol production in a marine cyanobacterium Synechococcus sp. PCC7002 through simultaneously removing glycogen synthesis genes and introducing ethanolgenic cassettes, Journal of biotechnology, 317:1-4.
  • Shen Tang#, Wei Zhang#, Zhimin Li, Hongcheng Li, Ce Geng, Xuenian Huang*, and Xuefeng Lu*, 2020, Discovery and Characterization of a PKS-NRPS Hybrid in Aspergillus terreus by Genome Mining, Journal of Natural Products, 83:473-480.
  • Yajing Liang #, Mingyi Zhang #, Min Wang, Wei Zhang, Cuncun Qiao, Quan Luo*, Xuefeng Lu*, 2020, Freshwater cyanobacterium Synechococcus elongatus PCC 7942 adapts to salt stress environment via ion-induced enzymatic balance of compatible solute, Applied and Environmental Microbiology, 86(7):e02904-19.
  • Xuenian Huang#, Wei Zhang#, Shen Tang#, Suhui Wei, Xuefeng Lu*, 2020, Collaborative Biosynthesis of a Class of Bioactive Azaphilones by Two Separate Gene Clusters Containing Four PKS/NRPSs with Transcriptional Crosstalk in Fungi. , Angew Chem Int Ed Engl, 132:4379 –4383.
  • Jacques Fritze, Mingyi Zhang, Quan Luo*, Xuefeng Lu*, 2020, An overview of the bacterial SsrA system modulating intracellular protein levels and activities, Applied Microbiology and Biotechnology, 104:5229–5241.
  • Yajing Liang, and Xuefeng Lu, 2019, Structural insights into the catalytic mechanism of lovastatin hydrolase, Journal of Biological Chemistry, 295(4):1047-1055.
  • Guodong Luan#, Shanshan Zhang#, Xuefeng Lu*, 2019, Engineering cyanobacteria chassis cells toward more efficient photosynthesis, Current Opinion in Biotechnology, 62:Pages 1-6,
  • Nitin Keshari, Muriel Gugger, Tao Zhu*, Xuefeng Lu*, 2019, Compatible solutes profiling and carbohydrate feedstock from diversified cyanobacteria, Algal Research,
  • Guodong Luan*, Shanshan Zhang, Min Wang, Xuefeng Lu*, 2019, Progress and perspective on cyanobacterial glycogen metabolism engineering, Biotechnology Advances,
  • Xuenian Huang, Shen Tang, Linghui Zheng, Yun Teng, Yong Yang, Jinwei Zhu, Xuefeng Lu*, 2019, Construction of an efficient and robust Aspergillus terreus cell factory for monacolin J production, ACS Synthetic Biology, 8(4):818-825.
  • Xintong Chi#, Shanshan Zhang#, Huili Sun, Yangkai Duan, Cuncun Qiao, Guodong Luan*, Xuefeng Lu*, 2019, Adopting a theophylline-responsive riboswitch for flexible regulation and understanding of glycogen metabolism in Synechococcus elongatus PCC 7942, Frontiers in Microbiology, doi: 10.3389/fmicb.2019.00551 .
  • Min Wang, Guodong Luan*, Xuefeng Lu*, 2019, Systematic identification of a neutral site on chromosome of Synechococcus sp. PCC7002, a promising photosynthetic chassis strain, Journal of Biotechnology, 295:37-40.
  • Cuncun Qiao, Mingyi Zhang, Quan Luo*, Xuefeng Lu*, 2019, Identification of two two‐component signal transduction mutants with enhanced sucrose biosynthesis in Synechococcus elongatus PCC 7942, Journal of Basic Microbiology, 59(5):465-476.
  • Friedrich Kirsch, Quan Luo, Xuefeng Lu, Martin Hagemann*, 2018, Inactivation of invertase enhances sucrose production in the cyanobacterium Synechocystis sp. PCC 6803, Microbiology-SGM, 164(10):1220-1228.
  • Xiaoming Tan#, Shengwei Hou#, Kuo Song, Jens Georg, Stephan Klähn, Xuefeng Lu*, Wolfgang R. Hess*, 2018, The primary transcriptome of the fast-growing cyanobacterium Synechococcus elongatus UTEX 2973, Biotechnology for Biofuels, 11:218.
  • Wenjing Lou#, Xiaoming Tan#, Kuo Song, Shanshan Zhang, Guodong Luan, Cheng Li, Xuefeng Lu*, 2018, A specific single nucleotide polymorphism in the ATP synthase gene significantly improves environmental stress tolerance of Synechococcus elongatus PCC 7942, Applied and Environmental Microbiology, 84(18):e01222-18.
  • Tao Zhu, Thibault Scalvenzi, Nathalie Sassoon, Xuefeng Lu*, Muriel Gugger*, 2018, Terminal olefin profiles and phylogenetic analyses of olefin synthases of diversified cyanobacterial species, Applied and Environmental Microbiology, 84(13):e00425-18.
  • Bo Liang, Xuenian Huang, Yun Teng, Yajing Liang, Yong Yang, Linghui Zheng, Xuefeng Lu*, 2018, Enhanced single-step bioproduction of the simvastatin precursor monacolin J in an industrial strain of Aspergillus terreus by employing the evolved lovastatin hydrolase, Biotechnology Journal, 10:e1800094.
  • Guodong Luan, Xuefeng Lu*, 2018, Tailoring cyanobacterial cell factory for improved industrial properties, Biotechnology Advances, 36(2):430-442.
  • Cuncun Qiao#, Yangkai Duan#, Mingyi Zhang, Martin Hagemann, Quan Luo*, Xuefeng Lu*, 2018, Effects of reduced and enhanced glycogen pools on salt-induced sucrose production in a sucrose-secreting strain of Synechococcus elongatus PCC 7942, Applied and Environmental Microbiology, 84(2):e02023-17.
  • Xuenian Huang, Yajing Liang, Yong Yang, Xuefeng Lu*, 2017, Single-step production of the simvastatin precursor monacolin J by engineering of an industrial strain of Aspergillus terreus, Metabolic Engineering, 42:109-114.
  • Kuo Song, Martin Hagemann, Xiaoming Tan*, Xuefeng Lu*, 2017, The response regulator Slr1588 regulates spsA but is not crucial for salt acclimation of Synechocystis sp. PCC 6803, Frontiers in Microbiology, 8:1176.
  • Huilin Mo, Xiaoman Xie, Tao Zhu*, Xuefeng Lu*, 2017, Effects of global transcription factor NtcA on photosynthetic production of ethylene in recombinant Synechocystis sp. PCC 6803, Biotechnology for Biofuels, 10:145.
  • Min Xie, Weihua Wang*, Weiwen Zhang, Lei Chen, Xuefeng Lu*, 2017, Versatility of hydrocarbon production in cyanobacteria, Applied Microbiology and Biotechnology, 101(3):905-919.
  • Tao Zhu#, Shengwei Hou#, Xuefeng Lu*, Wolfgang R Hess*, 2017, Draft genome sequences of nine cyanobacterial strains from diverse habitats, Genome Announcements, 5(9):e01676-16.
  • Qing Wang#, Luyao Bao#, Chenjun Jia, Mei Li, JianJun Li*, Xuefeng Lu*, 2017, Identification of residues important for the activity of aldehyde-deformylating oxygenase through investigation into the structure-activity relationship, BMC Biotechnology, 17(1):31.
  • Zhi Zhu, Guodong Luan*, Xiaoming Tan, Haocui Zhang, Xuefeng Lu*, 2017, Rescuing ethanol photosynthetic production of cyanobacteria in non-sterilized outdoor cultivations with a bicarbonate-based pH-rising strategy, Biothecnology for Biofuels, 10:93.
  • Lei Zhang, Yajing Liang, Wei Wu, Xiaoming Tan, Xuefeng Lu*, 2016, Microbial synthesis of propane by engineering valine pathway and aldehyde-deformylating oxygenase, Biotechnology for Biofuels, 9:80.
  • Min Wang, Xuefeng Lu*, 2016, Exploring the synergy between cellobiose dehydrogenase from Phanerochaete chrysosporium and cellulase from Trichoderma reesei, Frontiers in Microbiology, 7:620.
  • Xiaoming Tan, Quan Luo, Xuefeng Lu*, 2016, Biosynthesis, biotechnological production, and applications of glucosylglycerols, Applied Microbiology and Biotechnology, 100(14):6131-6139.
  • Philipp Savakis, Xiaoming Tan, Cuncun Qiao, Kuo Song, Xuefeng Lu, Klaas J. Hellingwerf, Filipe Branco dos Santos*, 2016, Slr1670 from Synechocystis sp. PCC 6803 is required for the re-assimilation of the osmolyte glucosylglycerol, Frontiers in Microbiology, 7:1350.
  • Luyao Bao, Jianjun Li*, Chenjun Jia, Mei Li, Xuefeng Lu*, 2016, Structure-oriented substrate specificity engineering of aldehyde-deformylating oxygenase towards aldehydes carbon chain length, Biotechnology for Biofuels, 9:185.
  • Kuo Song, Xiaoming Tan*, Yajing Liang, Xuefeng Lu*, 2016, The potential of Synechococcus elongatus UTEX 2973 for sugar feedstock production, Applied Microbiology and Biotechnology, 100(18):7865-7875.
  • Mei Chen, Xuenian Huang, Chengwei Zhong, Jianjun Li, Xuefeng Lu*, 2016, Identification of an itaconic acid degrading pathway in itaconic acid producing Aspergillus terreus, Applied Microbiology and Biotechnology, 100(17):7541-7548.
  • Xuenian Huang, Mei Chen, Jianjun Li, Xuefeng Lu*, 2016, Establishing an efficient gene-targeting system in an itaconic-acid producing Aspergillus terreus strain, Biotechnology Letters, 38(9):1603-1610.
  • Yangkai Duan, Quan Luo, Feiyan Liang, Xuefeng Lu*, 2016, Sucrose secreted by the engineered cyanobacterium and its fermentability, Journal of Ocean University of China, 15(5):890-896.
  • Guodong Luan#, Yunjing Qi#, Min Wang, Zhimin Li, Yangkai Duan, Xiaoming Tan, Xuefeng Lu*, 2015, Combinatory strategy for characterizing and understanding the ethanol synthesis pathway in cyanobacteria cell factories, Biotechnology for Biofuels, 8:184.
  • Wei Wu#, Lei Zhang#, Lun Yao, Xiaoming Tan, Xufeng Liu, Xuefeng Lu*, 2015, Genetically assembled fluorescent biosensor for in situ detection of bio-synthesized alkanes, Scientific Reports, 5:10907.
  • Tao Zhu#, Xiaoman Xie#, Zhimin Li, Xiaoming Tan, Xuefeng Lu*, 2015, Enhancing photosynthetic production of ethylene in genetically engineered Synechocystis sp. PCC 6803, Green Chemistry, 17(1):421-434.
  • Chenjun Jia, Mei Li*, Jianjun Li, Jingjing Zhang, Hongmei Zhang, Peng Cao, Xiaowei Pan, Xuefeng Lu*, Wenrui Chang*, 2015, Structural insights into the catalytic mechanism of aldehyde-deformylating oxygenases, Protein Cell, 6(1):55-67.
  • Xue Bao#, Xuenian Huang#, Xuefeng Lu, Jianjun Li*, 2014, Improvement of hydrogen peroxide stability of Pleurotus eryngii versatile ligninolytic peroxidase by rational protein engineering, Enzyme and Microbial Technology, 54(0):51-58.
  • Yi Liu, Cong Wang, Jinyong Yan, Wei Zhang, Wenna Guan, Xuefeng Lu, Shengying Li*, 2014, Hydrogen peroxide-independent production of alpha-alkenes by OleTJE P450 fatty acid decarboxylase, Biotechnology for Biofuels, 7(1):28.
  • Xuenian Huang, Xuefeng Lu, Jianjun Li*, 2014, Cloning, characterization and application of a glyceraldehyde-3-phosphate dehydrogenase promoter from Aspergillus terreus, Journal of Industrial Microbiology and Biotechnology, 41(3):585-592.
  • Qing Wang#, Xuenian Huang#, Jingjing Zhang, Xuefeng Lu, Shengying Li, Jian-Jun Li*, 2014, Engineering self-sufficient aldehyde deformylating oxygenases fused to alternative electron transfer systems for efficient conversion of aldehydes into alkanes, Chemical Communications, 50(33):4299-4301.
  • Lun Yao#, Fengxia Qi#, Xiaoming Tan, Xuefeng Lu*, 2014, Improved production of fatty alcohols in cyanobacteria by metabolic engineering, Biotechnology for Biofuels, 7:94.
  • Xuenian Huang, Xuefeng Lu, Yueming Li, Xia Li, Jian-Jun Li*, 2014, Improving itaconic acid production through genetic engineering of an industrial Aspergillus terreus strain, Microbial Cell Factories, 13(0):11.
  • Xuenian Huang, Mei Chen, Xuefeng Lu, Yueming Li, Jian-Jun Li*, 2014, Direct production of itaconic acid from liquefied corn starch by genetically engineered Aspergillus terreus, Microbial Cell Factories, 13(0):108.
  • Xiaoming Tan, Wei Du, Xuefeng Lu*, 2014, Photosynthetic and extracellular production of glucosylglycerol by genetically engineered and gel-encapsulated cyanobacteria, Applied Microbiology and Biotechnology, 99(0):2147-2154.
  • PhiliSavakis, Xiaoming Tan, Wei Du, Filipe Branco dos Santos, Xuefeng Lu, Klaas J. Hellingwerf*, 2014, Photosynthetic production of glycerol by a recombinant cyanobacterium, Journal of Biotechnology, 195(0):46-51.
  • Jingjing Zhang, Xuefeng Lu*, Jianjun Li*, 2013, Conversion of fatty aldehydes into alk (a/e)nes by in vitro reconstituted cyanobacterial aldehyde-deformylating oxygenase with the cognate electron transfer system, Biotechnology for Biofuels, 6(1):86.
  • Zhi Zhu#, Liu Yang#, Weihua Wang, Xuefeng Lu*, 2013, Microbial recycling of glycerol to biodiesel, Bioresource Technology, 150(0):1-8.
  • Fengxia Qi, Lun Yao, Xiaoming Tan, Xuefeng Lu*, 2013, Construction, characterization and application of molecular tools for metabolic engineering of Synechocystis sp., Biotechnology Letters, 35(10):1655-1661.
  • Aiqiu Liu#, Tao Zhu#, Xuefeng Lu*, Lirong Song, 2013, Hydrocarbon profiles and phylogenetic analyses of diversified cyanobacterial species, Applied Energy, 111(0):383-393.
  • Aiqiu Liu, Xiaoming Tan, Lun Yao, Xuefeng Lu*, 2013, Fatty alcohol production in engineered E. coli expressing Marinobacter fatty acyl-CoA reductases, Applied Microbiology and Biotechnology, 97(15):7061-7071.
  • Wei Du#, Feiyan Liang#, Yangkai Duan, Xiaoming Tan, Xuefeng Lu*, 2013, Exploring the photosynthetic production capacity of sucrose by cyanobacteria, Metabolic Engineering, 19(0):17-25.
  • Qianqian Gao, Xiaoming Tan, Xuefeng Lu*, 2013, Enzymatic and physiological characterization of fatty acid activation in Synechocystis sp. PCC6803, Journal of Basic Microbiology, 53(10):848-855.
  • Xiaoming Tan, Feiyan Liang, Ke Cai, Xuefeng Lu*, 2013, Application of the FLP/FRT recombination system in cyanobacteria for construction of markerless mutants, Applied Microbiology and Biotechnology, 14(97):6373-6382.
  • Weihua Wang#, Xufeng Liu#, Xuefeng Lu*, 2013, Engineering cyanobacteria to improve photosynthetic production of alka(e)nes, Biotechnology for Biofuels, 6:69-77.
  • Weihua Wang, Xuefeng Lu*, 2013, Microbial synthesis of alka(e)nes, Frontiers in Bioengineering and Biotechnology, 1(1):1-5.
  • Xiaoming Tan, Weihua Wang, Xuefeng Lu*, 2012, Production of photosynthetic biofuels by genetically engineering cyanobacteria, Current Chemical Biology, 6(1):26-31.
  • Qianqian Gao, Weihua Wang, Hui Zhao, Xuefeng Lu*, 2012, Effects of fatty acid activation on photosynthetic production of fatty acid-based biofuels in Synechocystis sp. PCC6803, Biotechnology for Biofuels, 5(1):17.
  • Xue Bao, Aiqiu Liu, Xuefeng Lu, Jianjun Li*, 2012, Direct over-expression, characterization and H2O2 stability study of active Pleurotus eryngii versatile peroxidase in Escherichia coli, Biotechnology Letters, 34(8):1537-1543.
  • Zhengxu Gao#, Hui Zhao#, Zhimin Li, Xiaoming Tan, Xuefeng Lu*, 2012, Photosynthetic production of ethanol from carbon dioxide in genetically engineered cyanobacteria, Energy & Environmental Science, 5(12):9857-9865.
  • Xiaoming Tan#, Lun Yao#, Qianqian Gao, Weihua Wang, Fengxia Qi, Xuefeng Lu*, 2011, Photosynthesis driven conversion of carbon dioxide to fatty alcohols and hydrocarbons in cyanobacteria, Metabolic Engineering, 13(2):169-176.
  • Yangkai Duan#, Zhi Zhu#, Ke Cai, Xiaoming Tan, Xuefeng Lu*, 2011, De novo biosynthesis of biodiesel by Escherichia coli in optimized fed-batch cultivation, PLos One, 6(5):e20265.
  • Wenna Guan*, Hui Zhao, Xuefeng Lu*, Cong Wang, Menglong Yang, Fali Bai, 2011, Quantitative analysis of fatty-acid-based biofuels produced by wild-type and genetically engineered cyanobacteria by gas chromatography-mass spectrometry, Journal of Chromatography A, 1218(45):8289-8293 .
  • Xuefeng Lu*, 2010, A perspective: Photosynthetic production of fatty acid-based biofuels in genetically engineered cyanobacteria, Biotechnology Advances, 28(6):742-746.
before 2010
  • Jian Dong, Paul R. Carey*, Yansheng Wei, Lusong Luo, Xuefeng Lu, Ruiqin Liu, Debra Dunaway-Mariano*, 2002, Raman evidence for Meisenheimer complex formation in the hydrolysis reactions of 4-fluorobenzoyl- and 4-nitrobenzoyl-coenzyme a catalyzed by 4-chlorobenzoyl-coenzyme a dehalogenase, Biochemistry, 41(23):7453-7463.
  • Jian Dong, Xuefeng Lu, Yansheng Wei, Lusong Luo, Debra Dunaway-Mariano*, Paul R. Carey*, 2003, The strength of dehalogenase-substrate hydrogen bonding correlates with the rate of Meisenheimer intermediate formation, Biochemistry, 42(31):9482-9490.
  • Xuefeng Lu, Andrey Galkin, Osnat Herzberg, Debra Dunaway-Mariano*, 2004, Arginine deiminase uses an active-site cysteine in nucleophilic catalysis of L-arginine hydrolysis, Journal of the American Chemical Society, 126(17):5374-5375.
  • Andrew M. Gulick*, Xuefeng Lu, Debra Dunaway-Mariano, 2004, Crystal structure of 4-chlorobenzoate: CoA ligase/synthetase in the unliganded and aryl substrate-bound states, Biochemistry, 43(27):8670-8679.
  • Andrey Galkin, Xuefeng Lu, Debra Dunaway-Mariano, Osnat Herzberg*, 2005, Crystal structures representing the michaelis complex and the thiouronium reaction intermediate of Pseudomonas aeruginosa arginine deiminase, Journal of Biological Chemistry, 280(40):34080-34087.
  • Xuefeng Lu, Ling Li, Xiaohua Feng, Yan Wu, Debra Dunaway-Mariano, John R. Engen, Patrick S. Mariano*, 2005, L-canavanine is a time-controlled mechanism-based inhibitor of Pseudomonas aeruginosa arginine deiminase, Journal of the American Chemical Society , 127(47):16412-16413.
  • Jingbo Wu, Dingguo Xu, Xuefeng Lu, Canhui Wang, Hua Guo*, Debra Dunaway-Mariano*, 2005, ontributions of long-range electrostatic interactions to 4-chlorobenzoyl-CoA dehalogenase catalysis: a combined theoretical and experimental study, Biochemistry, 45(1):102-112.
  • Xuefeng Lu, Ling Li, Rui Wu, Xiaohua Feng, Zhimin Li, Heyi Yang, Canhui Wang, Hua Guo, Andrey Galkin, Osnat Herzberg, Patrick. S. Mariano, Brian M. Martin, Debra Dunaway-Mariano*, 2006, Kinetic analysis of Pseudomonas aeruginosa arginine deiminase mutants and alternate substrates provides insight into structural determinants of function, Biochemistry, 45(4):1162-1172.
  • Ling Li, Zhimin Li, Danqi Chen, Xuefeng Lu, Xiaohua Feng, Elizabeth C. Wright, Nathan O. Solberg, Debra Dunaway-Mariano*, Patrick S. Mariano*, 2008, Inactivation of microbial arginine deiminases by L-canavanine, Journal of the American Chemical Society, 130(6):1918-1931.
  • Rui Wu, Jian Cao, Xuefeng Lu, Albert S. Reger, Andrew. M. Gulick, Debra Dunaway-Mariano*, 2008, Mechanism of 4-chlorobenzoate: Coenzyme a ligase catalysis, Biochemistry, 47(31):8026-8039.
  • Xuefeng Lu, Harmit Vora, Chaitan Khosla*, 2008, Overproduction of free fatty acids in E. coli: implications for biodiesel production, Metabolic Engineering, 10(6):333-339.
  • Rui Wu, Albert. S. Reger, Xuefeng Lu, 2009, Andrew. M. Gulick*, Debra Dunaway-Mariano*, The mechanism of domain alternation in the acyl-adenylate forming ligase superfamily member 4-chlorobenzoate: coenzyme a ligase, Biochemistry, 48(19):4115-4125.
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