丝状真菌是一类非常重要的工业微生物，在医药、食品、化工和农业领域都具有广泛的应用。微生物制造工程中心聚焦重要医药产品生产工艺复杂低效的共性问题，通过发展合成生物技术推动多个重要产品生产工艺的绿色升级，低产到优产、多步变少步、生物催化替代化学合成、微生物发酵取代传统植物提取，提高工业过程的经济效益与环保效益。打通了降血脂药物辛伐他汀的全生物合成技术路线，建立了杀线剂 F606 的微生物发酵生产线，实现了中药大黄活性成分大黄素甲醚的微生物高效合成。多项成果与海正药业、鲁抗医药等国内知名企业实现技术转让，推动传统生产工艺的绿色升级和新型生物农药创制。

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1. Xuenian Huang, Ping Men, Shen Tang, Xuefeng Lu*, 2021，Aspergillus terreus as an industrial filamentous fungus for pharmaceutical biotechnology. Current Opinion in Biotechnology，69，273-280.

2. Xuenian Huang, Shen Tang, Linghui Zheng, Yun Teng, Yong Yang, Jinwei Zhu, Xuefeng Lu*, 2019, Construction of an efficient and robust Aspergillus terreus cell factory for monacolin J production, ACS Synthetic Biology, 8(4):818-825

3. Bo Liang, Xuenian Huang, Yun Teng, Yajing Liang, Yong Yang, Linghui Zheng, Xuefeng Lu*, 2018, Enhanced single-step bioproduction of the simvastatin precursor monacolin J in an industrial strain of Aspergillus terreus by employing the evolved lovastatin hydrolase, Biotechnology Journal, 10:e1800094

4. Xuenian Huang, Yajing Liang, Yong Yang, Xuefeng Lu*, 2017, Single-step production of the  simvastatin precursor monacolin J by engineering of an industrial strain of Aspergillus terreus, Metabolic Engineering, 42:109-114

5. Xuenian Huang, Mei Chen, Jianjun Li, Xuefeng Lu*, 2016, Establishing an efficient gene-targeting system in an itaconic-acid producing Aspergillus terreus strain, Biotechnology Letters, 38(9):1603-1610

6. Mei Chen, Xuenian Huang, Chengwei Zhong, Jianjun Li, Xuefeng Lu*, 2016, Identification of an itaconic acid degrading pathway in itaconic acid producing Aspergillus terreus, Applied Microbiology and Biotechnology, 100(17):7541-7548

7. Xuenian Huang, Mei Chen, Xuefeng Lu, Yueming Li, Jian-Jun Li*, 2014, Direct production of itaconic acid from liquefied corn starch by genetically engineered Aspergillus terreus, Microbial Cell Factories, 13(0):108

8. Xuenian Huang, Xuefeng Lu, Yueming Li, Xia Li, Jian-Jun Li*, 2014, Improving itaconic acid production through genetic engineering of an industrial Aspergillus terreus strain, Microbial Cell Factories, 13(0):119

9. Xuenian Huang, Xuefeng Lu, Jianjun Li*, 2014, Cloning, characterization and application of a glyceraldehyde-3-phosphate dehydrogenase promoter from Aspergillus terreus, Journal of Industrial Microbiology and Biotechnology, 41(3):585-592