Professor, Vice director of Center, Leader of Cyanobacterial Synthetic Biotechnology Group Research Interest Physiological and metabolic engineering of cyanobacteria for development of efficient photosynthetic cell factories Understanding and engineering cyanobacteria cellualr tolerances toward environmental stresses Microbial adaptive evolution, including the mechanisms and methods Career Experience 2020-Present, Leader of Cyanobacterial Synthetic Biotechnology Group, Qingdao Institute of Bioenergy and Bioprocess Technology CAS; 2017-Present, Associate Professor, Qingdao Institute of Bioenergy and Bioprocess Technology CAS; 2016-2017, Assistant Professor, Qingdao Institute of Bioenergy and Bioprocess Technology CAS; 2014-2016, Post-doctor, Qingdao Institute of Bioenergy and Bioprocess Technology CAS; Education Experience 2008-2014,Institute of Microbiology, Chinese Academy of Sciences, Ph.D. 2004-2008, Shandong University, Bachelor. Publications Luan, G., Lu, X.*, (2018) Tailoring cyanobacterial cell factory for improved industrial properties. Biotechnology Advances, 36(2):430-442. Luan, G.*, Zhang, S., Wang, M., Lu, X.*, (2019) Progress and perspective on cyanobacteria glycogen metabolism engineering. Biotechnology Advances, 37(5):771-786. Luan, G., Cai, Z.*, Gong, F., Dong, H., Lin, Z., Zhang, Y. and Li, Y.*, (2013) Developing controllable hypermutable Clostridium cells through manipulating its methyl-directed mismatch repair system. Protein & Cell, 4, 854-862. Luan, G.#, Zhang#, S., Lu, X.*, (2019) Engineering cyanobacteria chassis cells toward more efficient photosynthesis. Current Opinion in Biotechnology, 62:1-6. Luan, G., Cai, Z.*, Li, Y.* and Ma, Y., (2013) Genome replication engineering assisted continuous evolution (GREACE) to improve microbial tolerance for biofuels production. Biotechnology for Biofuels, 6:137. Luan, G.#,Qi, Y.#, Wang, M., Li, Z., Duan, Y., Tan, X., and Lu, X.*, (2015) Combinatory strategy for characterizing and understanding the ethanol synthesis pathway in cyanobacteria cell factories. Biotechnology for Biofuels, 8, 184. Zhu, Z.,Luan, G.*, Tan, X., Zhang, H., and Lu, X.*, (2017) Rescuing ethanol photosynthetic production of cyanobacteria in non-sterilized outdoor cultivations with a bicarbonate-based pH-rising strategy. Biotechnology for Biofuels, 10:93. Luan, G.#,Bao, G.#, Lin, Z., Li, Y., Chen, Z., Li, Y., Cai, Z.*, (2015) Comparative genome analysis of a thermotolerant Escherichia coli obtained by Genome Replication Engineering Assisted Continuous Evolution (GREACE) and its parent strain provides new understanding of microbial heat tolerance. New Biotechnology, 32(6):732-738. Chi, X.#, Zhang, S.#, Sun, H., Duan, Y., Qiao, C.Luan, G.*, Lu, X.*, (2019) Adopting a theophylline-responsive riboswitch for flexible regulation and understanding of glycogen metabolism in Synechococcus elongatus PCC7942. Frontiers in Microbiology, 10:551. Zhang, M., Qiao, C.,Luan, G.*, Luo, Q.*, Lu, X., (2020) Systematic Identification of Target Genes for Cellular Morphology Engineering in Synechococcus elongatus PCC7942. Frontiers in Microbiology, 11:1608. Luan, G.#, Dong, H.#, Zhang, T., Lin Z., Zhang, Y., Li, Y., Cai, Z.*, (2014) Engineering cellular robustness of microbes by introducing the GroESL chaperonins from extremophilic bacteria. Journal of Biotechnology, 178, 38-40. Wang, M.,Luan, G.*, Lu, X.*, (2019) Systematic identification of a neutral site on chromosome of Synechococcus sp. PCC7002, a promising photosynthetic chassis strain. Journal of Biotechnology, 295:37-40. Wang, M.,Luan, G.*, Lu, X.*, (2020) Engineering ethanol production in a marine cyanobacterium Synechococcus sp. PCC7002 through simultaneously removing glycogen synthesis genes and introducing ethanolgenic cassettes. Journal of Biotechnology, 317:1-4. Zhang, S., Zheng, S. Sun, J., Zeng, X., Duan, Y.,Luan, G.*, Lu, X.*, (2021) Rapidly improving high light and high temperature tolerances of cyanobacteria cell factories through convenient introduction of an AtpA-C252F mutation. Frontiers in Microbiology. (Accepted).
