蓝细菌广泛分布于海洋、陆地、淡水和极地等生态系统中，是研究微生物环境适应机制的重要模式体系。在光合生物制造过程中，蓝细菌细胞工厂同样需要面对各种逆境胁迫的挑战。因此，解析蓝细菌对逆境胁迫的适应机制、提升蓝细菌底盘和细胞工厂的抗逆能力，具有重要的科学和技术意义。

微生物制造工程中心从各类极端生境中采集了具有优良抗逆能力的天然藻种资源，创制了可控超突变等蓝细菌生理功能快速优化技术，进而综合应用合成生物技术、系统生物技术、生物化学及分子生物学等多维手段，成功解析了蓝细菌抵抗高温、高光、高盐等各类逆境胁迫的分子模式并鉴定获得抗逆功能基因，以上述抗逆机制的解析和抗逆基因的鉴定为基础，成功提升了蓝细菌底盘细胞和光合细胞工厂面临复杂培养环境与过程的光合效能与稳定性。基于上述研究，在Nature Communications、Applied and Environmental Microbiology、Biotechnology for Biofuels等期刊发表论文十余篇。

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