蓝细菌广泛分布于海洋、陆地、淡水和极地等生态系统中，是研究微生物环境适应机制的重要模式体系。在光合生物制造过程中，蓝细菌细胞工厂同样需要面对各种逆境胁迫的挑战。因此，解析蓝细菌对逆境胁迫的适应机制具有重要的科学和技术意义。
微生物制造工程中心采集丰富的藻种资源，应用合成生物技术、系统生物技术、生物化学及分子生物学等多维手段对蓝细菌抵抗逆境胁迫的分子模式进行解析。针对蓝细菌高盐耐受机制，从"感知-传导-调控-代谢”等多个层面上进行系统研究，揭示了聚球藻 PCC 7942 细胞通过“离子浓度介导的酶活协同调控”机制，快速调节蔗糖合成过程中“合成酶-降解酶”酶活以积累蔗糖、平衡胞内外渗透压差的适应策略。针对蓝细菌高温高光耐受机制，发现细胞能量代谢核心模块 FoF1-ATP 合成酶对高温高光耐受性具有重要影响，其 alpha 亚基上单一氨基酸突变（C252Y）即可赋予藻株适应高温高光胁迫并快速积累生物质的能力。
相关文章：
Shanshan Zhang, Sini Zheng, Jiahui Sun, Xuexia Zeng, Yangkai Duan, Guodong Luan*, Xuefeng Lu*. Rapidly improving high light and high temperature tolerances of cyanobacteria cell factories through convenient introduction of an AtpA-C252F mutation. Frontiers in Microbiology. 2021, 12 (523).
Yajing Liang #, Mingyi Zhang #, Min Wang, Wei Zhang, Cuncun Qiao, Quan Luo*, Xuefeng Lu*, 2020, Freshwater cyanobacterium Synechococcus elongatus PCC 7942 adapts to salt stress environment via ion-induced enzymatic balance of compatible solute, Applied and Environmental Microbiology, 86(7):e02904-19.
Yue Qiao, Weihua Wang*, Xuefeng Lu*, 2020, High Light Induced Alka(e)ne Biodegradation for Lipid and Redox Homeostasis in Cyanobacteria, Frontiers in Microbiology, 11:1659.
Cuncun Qiao, Mingyi Zhang, Quan Luo*, Xuefeng Lu*, 2019, Identification of two two-component signal transduction mutants with enhanced sucrose biosynthesis in Synechococcus elongatus PCC 7942, Journal of Basic Microbiology, 59(5):465-476.
Wenjing Lou#, Xiaoming Tan#, Kuo Song, Shanshan Zhang, Guodong Luan, Cheng Li, Xuefeng Lu*, 2018, A specific single nucleotide polymorphism in the ATP synthase gene significantly improves environmental stress tolerance of Synechococcus elongatus PCC 7942, Applied and Environmental Microbiology, 84(18):e01222-18.
Xiaoming Tan#, Shengwei Hou#, Kuo Song, Jens Georg, Stephan Klähn, Xuefeng Lu*, Wolfgang R. Hess*, 2018, The primary transcriptome of the fast-growing cyanobacterium Synechococcus elongatus UTEX 2973, Biotechnology for Biofuels, 11:218.
